Santai's R&D team achieves the extraction of the highest purity (＞99%) NMN, ensuring each capsule is filled with a reassuring "white powder." If you were to open each capsule, you would find no trace of suspicious chemical solvent residues. Such confidence stems not only from our faith in developing natural raw materials but also from our nearly 30 years of production experience in a GMP-certified factory.

In terms of NMN extraction and production, we are always willing to go the extra mile, a dedication driven by our trust in NMN's efficacy.

How is NMN effective?

Metabolism of Substances and Energy:

Once NMN is ingested and transformed into NAD+, it plays a crucial role in energy and substance metabolism.

Preventing Age-Related Physiological Decline:

As NAD+ levels decrease with age, mice supplemented with NMN have shown weight reduction, increased energy, better blood glucose control, and an improvement in age-related physiological decline.

1. DNA Repair Enzymes:

NAD+ is the sole substrate for ADP-ribosyltransferases or poly (ADP-ribose) polymerases (PARPs), located in various cellular nuclei. When free radicals and oxidants damage cells, DNA single-strands break, activating PARP. Activated PARP uses coenzyme I (NAD+) as a substrate to transfer ADP-ribose to target proteins, generating nicotinamide (Nam), with these proteins involved in DNA repair, gene expression, cell cycle progression, cell survival, chromosomal restructuring, and gene stability.

2. Cyclic ADP-Ribose Synthetase:

NAD+ is the only substrate for cyclic ADP-ribose synthetases (cADPRsynthases) or cyclic ribosyl polymerases. These enzymes, including lymphocyte antigens CD38 and CD157, use NAD+ to produce cyclic ADP-ribose, a secondary messenger in cell cycles and insulin response.

3. Deacetylases:

NAD+ is the exclusive substrate for the longevity proteins, type III lysine deacetylases, Sirtuins. Present in mammals, composed of 275 amino acids, and coming in seven different subtypes (SIRT1-SIRT7), Sirtuins play a significant role in cellular stress resistance, energy metabolism, cell apoptosis, and aging processes. For example, SIRT1 can activate PARP-1 for efficient DNA double-strand repair, while SIRT3-5 can act as tumor suppressors.

Improvement of Type II Diabetes and Prevention of Neurodegenerative Diseases:

1. Improvement of Type II Diabetes:

Type II diabetes, a modern epidemic, is believed to result from high-calorie diets and sedentary lifestyles disrupting our natural sugar metabolism pathways. One theory posits that high-calorie consumption disrupts NAD+ biosynthesis, while NMN supplementation can increase insulin sensitivity and improve age-induced glucose intolerance.

2. Prevention of Neurodegenerative Diseases (Parkinson’s, Dementia):

NAD+ supplementation has shown to enhance neuroprotection against traumatic brain injury, Parkinson's, and amyotrophic lateral sclerosis, normalizing neuromuscular function and delaying memory decline. In Alzheimer's disease, reduced NAMPT and impaired neural stem cell differentiation have been observed. High NAMPT activity or NAD+ supplementation reduces β-amyloid accumulation, enhancing Alzheimer's condition through PGC-1α-mediated β-secretase (BACE1) degradation and induced mitochondrial biosynthesis.

NAD+ Benefits for Skin:

1. High Permeability:

NAD+ can quickly reach the dermis and subcutaneous tissue, being rapidly absorbed by the skin. It stimulates cellular activation internally, enhances epidermal cell activity, restores healthy skin, and achieves anti-aging effects.

2. Promotes DNA Repair:

It fosters skin cell DNA repair and integrity, preventing keratinization and skin cancer caused by UV and light exposure.

3. Enhances Energy Synthesis:

It encourages the active transport of nutrients from outside the cell, increasing intracellular nutrition, speeding up the generation of new cells, promoting the secretion and synthesis of functional molecules like collagen, polysaccharides, and glycoproteins in the dermis, repairing broken and degenerated collagen and elastic fibers, and maintaining tight, orderly muscle fibers, resulting in fuller, more elastic skin, reducing wrinkles, and restoring youthful vitality.

NMN 12000

JP¥92,000

Quantity

NMN is a precursor of NAD+, and its function is manifested through NAD+. NAD+, also known as Coenzyme I, full name Nicotinamide Adenine Dinucleotide, is present in every cell and participates in thousands of reactions.

NAD+ is an essential coenzyme in the citric acid cycle, promoting the metabolism of sugars, fats, and amino acids, and participating in energy synthesis.

NAD+ is also the only substrate for Coenzyme I-consuming enzymes (the sole substrate for DNA repair enzyme PARP, longevity proteins Sirtuins, and cyclic ADP-ribose synthase CD38/157).

NMN is produced under the catalysis of Nampt, and subsequently, NAD+ is generated under the catalysis of nicotinamide mononucleotide adenylyl transferase (Nmnat). NMN exerts its physiological functions in the human body by converting to NAD+, such as activating the NAD+-dependent enzyme Sirt1 (a histone deacetylase, also known as a silent regulator protein), regulating cell survival and death, maintaining the redox status, and more. Sirt1 is an NAD+-dependent enzyme, and supplementing NMN accelerates the turnover of the salvage biosynthesis of NAD+, thereby activating the Sirt1 reaction. Sirt1 can induce DNA silencing, contributing to anti-aging and life extension. Due to its large molecular size, NAD+ cannot be directly taken into cells by oral ingestion and must be supplemented by consuming precursors of NAD+ with smaller molecular sizes.

The Sinclair Lab at Harvard University and the Shin-ichiro Imai Lab at Washington University independently confirmed that by orally consuming a naturally occurring NAD+ precursor substance—NMN—it is possible to effectively increase the NAD+ content in various organs of the body, such as blood, skin, muscles, heart, and brain, and significantly inhibit the metabolic decline and weight gain caused by aging. Furthermore, the ATP content in the bodies of older animals taking NMN also returned to the levels found in younger animals.
NAD+ has three independent metabolic pathways in the human body: the Preiss-Handler pathway, de novo synthesis pathway, and salvage synthesis pathway. NAD+ undergoes three consumption pathways:

1. Sirtuins (deacetylating enzymes) are important for cellular stress resistance, energy metabolism, cell apoptosis, and aging.
2. PARPs (DNA repair enzymes) participate in DNA repair, gene expression, cell cycle progression, cell survival, chromosomal reconstruction, and genetic stability.
3. cADPR (cyclic ADP ribose synthetase) is a second messenger for the cell cycle and insulin, playing a significant role in the immune system response.

A study from the Center for Healthy Aging and the National Institutes of Health found that NAD+ plays a vital role during aging. This research indicated that as age increases, the levels of NAD+ in the body decline. This reduction is more pronounced in prematurely aging tissues and those lacking DNA repair. Researchers discovered that increasing NAD+ levels in the body could delay the cellular aging process. They found from related studies that a decrease in NAD+ levels leads to metabolic disorders, neurodegenerative diseases, and aging. By supplementing intracellular NAD+ levels, the severity of Ataxia-Telangiectasia (A-T) can be reduced. Increasing intracellular NAD+ can promote neurons to conduct DNA repair and improve mitochondrial function through mitophagy.
"NMN is the most direct supplement to replenish NAD+

NMN bypasses the bottleneck of the NAMPT rate-limiting enzyme, rapidly replenishing NAD+ in the body. In a 2017 study, after supplementing with NMN for four days, there was a significant increase in the activity of NAD+ and SIRT1 in the body. The levels of NAD+ and SIRT1 activity in elderly mice taking NMN were higher than those in young mice not taking NMN.

NMN supplementation is superior to NR

Both NMN and NR are more direct means of supplementing NAD+. After entering the body, NR requires phosphorylation by NPK1 and NPK2 to turn into NMN, and there are no NPK1 and NPK2 enzymes in the mitochondria to convert NR into NMN. Orally administered NR is digested into NAM in the body, still unable to change the restriction of the salvage synthesis pathway's rate-limiting enzyme, NAMPT, limiting its ability to supplement NAD+. Therefore, supplementing with NMN is a direct and effective way to replenish NAD+.

NMN has no side effects and is rapidly absorbed by the body.

NMN itself is a substance naturally occurring in the human body and is also found in many foods, purely natural and harmless. Research has confirmed that supplementing with NMN does not affect the activity of various enzymes in the salvage synthesis pathway. After oral administration, NMN does not impact the activity of various enzymes in the salvage synthesis pathway, such as NAMPT, PARP, NMNAT, etc., directly altering the level of NAD+ in the body.

NMN is absorbed very quickly in the body, rapidly increasing the level of NAD+:
1.) It is absorbed intact through the digestive system;
2.) Enters the bloodstream within 2-3 minutes;
3.) Raises tissue levels of NMN within 15 minutes;
4.) Rapidly increases the levels of NAD+ in the blood, liver, and other organs.

How is NMN effective?

Metabolism of Substances and Energy:

Preventing Age-Related Physiological Decline:

Improvement of Type II Diabetes and Prevention of Neurodegenerative Diseases:

NMN 12000

Introduction to NMN

Introduction to NAD+

Why do we use NMN to supplement NAD+ instead of other supplements?

"NMN is the most direct supplement to replenish NAD+

NMN supplementation is superior to NR

NMN has no side effects and is rapidly absorbed by the body.